Kidney and Recipient Weight Incompatibility Reduces Long-Term Graft Survival

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Kidney and recipient weight incompatibility reduces long-term graft survival.

Long-term function of kidney allografts depends on multiple variables, one of which may be the compatibility in size between the graft and the recipient. Here, we assessed the long-term consequences of the ratio of the weight of the kidney to the weight of the recipient (KwRw ratio) in a multicenter cohort of 1189 patients who received a transplant between 1995 and 2006. The graft filtration ra...

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The association between recipient alcohol dependency and long-term graft and recipient survival.

BACKGROUND The causative role of alcohol consumption in renal disease is controversial, and its effect on renal graft and recipient survival has not been previously studied. METHODS We analysed the association between pre-transplant [at the time of end-stage renal disease (ESRD) onset] alcohol dependency and renal graft and recipient survival. The United States Renal Data System (USRDS) recor...

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Clinical and histological predictors of long-term kidney graft survival.

Renal transplantation is the best option for patients with end-stage renal disease (ESRD), but its half-life is limited to a decade. Clinical and histological markers measurable within the first year of transplantation can be used to predict its outcome. These markers are important for selecting kidneys for transplantation, for identifying the main causes of late allograft loss, for therapeutic...

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PAI-1 donor polymorphism influences long-term kidney graft survival.

BACKGROUND The type 1 plasminogen activator inhibitor (PAI-1) is involved in the development of fibrosis, and its intrarenal expression is increased in interstitial fibrosis and tubular atrophy (IFTA). Moreover, a 4G/5G polymorphism of the PAI-1 gene has been described associating 4G haplotype with higher PAI-1 plasma activity. We investigated the relationship between the donor and recipient PA...

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Effect of donor/recipient body weight ratio, donor weight, recipient weight and donor age on kidney graft function in children.

BACKGROUND We hypothesized that supplementing a higher mass of renal parenchyma from adult donors, and their younger age, would improve graft function in paediatric recipients. METHODS We calculated estimated glomerular filtration rate (eGFR; Schwartz formula) and absolute glomerular filtration rate (absGFR) in 57 renal-grafted children (1995-2007) aged 3.1-17.9 years, weighing 12.9-85.0 kg, ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2010

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2009121296